USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

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Searching in 'USC-OGP 2-DE database' for entry matching: PHS_HUMAN USC-OGP 2-DE database:  PHS_HUMAN PHS_HUMAN General information about the entry View entry in simple text format Entry name PHS_HUMAN Primary accession number P61457 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Pterin-4-alpha-carbinolamine dehydratase; Short=PHS; EC=4.2.1.96; AltName: Full=4-alpha-hydroxy-tetrahydropterin dehydratase; AltName: Full=Dimerization cofactor of hepatocyte nuclear factor 1-alpha; Short=DCoH; Short=Dimerization cofactor of HNF1; AltName: Full=Phenylalanine hydroxylase-stimulating protein; AltName: Full=Pterin carbinolamine dehydratase; Short=PCD;. Gene name Name=PCBD1 Synonyms=DCOH, PCBD Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1357: pI=6.51; Mw=13033 Cross-references UniProtKB/Swiss-Prot P61457; PHS_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name PHS_HUMAN Primary accession number P61457 Secondary accession number(s) P70519 P80095 Q9D930 Sequence was last modified on  January 23, 2007 (version 2) Annotations were last modified on  March 15, 2017 (version 136) Name and origin of the protein Description RecName: Full=Pterin-4-alpha-carbinolamine dehydratase; Short=PHS; EC=4.2.1.96; AltName: Full=4-alpha-hydroxy-tetrahydropterin dehydratase; AltName: Full=Dimerization cofactor of hepatocyte nuclear factor 1-alpha; Short=DCoH; Short=Dimerization cofactor of HNF1; AltName: Full=Phenylalanine hydroxylase-stimulating protein; AltName: Full=Pterin carbinolamine dehydratase; Short=PCD; Gene name Name=PCBD1 Synonyms=DCOH, PCBD Encoded on Name=PCBD1; Synonyms=DCOH, PCBD Keywords Acetylation; Activator; Complete proteome; Cytoplasm; Direct protein sequencing; Disease mutation; Lyase; Nucleus; Reference proteome; Tetrahydrobiopterin biosynthesis; Transcription; Transcription regulation. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL M83742; -; NOT_ANNOTATED_CDS; mRNA EMBL L41560; AAA69662.1; -; Genomic_DNA EMBL L41559; AAA69663.1; -; mRNA EMBL AF082858; AAD25732.1; -; mRNA EMBL BC006324; AAH06324.1; -; mRNA CCDS CCDS31217.1; -; . PIR A47010; A47010; . RefSeq NP_000272.1; NM_000281.3; . RefSeq NP_001276726.1; NM_001289797.1; . UniGene Hs.3192; -; . ProteinModelPortal P61457; -; . SMR P61457; -; . BioGrid 111125; 62; . IntAct P61457; 49; . MINT MINT-1436903; -; . STRING 9606.ENSP00000299299; -; . iPTMnet P61457; -; . PhosphoSitePlus P61457; -; . BioMuta PCBD1; -; . DMDM 47606444; -; . UCD-2DPAGE P61457; -; . EPD P61457; -; . MaxQB P61457; -; . PaxDb P61457; -; . PeptideAtlas P61457; -; . PRIDE P61457; -; . Ensembl ENST00000299299; ENSP00000299299; ENSG00000166228; . GeneID 5092; -; . KEGG hsa:5092; -; . UCSC uc001jrn.3; human; . CTD 5092; -; . DisGeNET 5092; -; . GeneCards PCBD1; -; . HGNC HGNC:8646; PCBD1; . HPA HPA037575; -; . HPA HPA061723; -; . MalaCards PCBD1; -; . MIM 126090; gene; . MIM 264070; phenotype; . neXtProt NX_P61457; -; . OpenTargets ENSG00000166228; -; . Orphanet 1578; Dehydratase deficiency; . PharmGKB PA32985; -; . eggNOG KOG4073; Eukaryota; . eggNOG COG2154; LUCA; . GeneTree ENSGT00390000007221; -; . HOGENOM HOG000007680; -; . HOVERGEN HBG000259; -; . InParanoid P61457; -; . KO K01724; -; . OMA IKAQEMD; -; . OrthoDB EOG091G120V; -; . PhylomeDB P61457; -; . TreeFam TF300188; -; . BioCyc MetaCyc:HS09360-MONOMER; -; . Reactome R-HSA-71182; Phenylalanine and tyrosine catabolism; . GeneWiki PCBD1; -; . GenomeRNAi 5092; -; . PRO PR:P61457; -; . Proteomes UP000005640; Chromosome 10; . Bgee ENSG00000166228; -; . CleanEx HS_PCBD1; -; . Genevisible P61457; HS; . GO GO:0005829; C:cytosol; IDA:HPA; . GO GO:0070062; C:extracellular exosome; IDA:UniProtKB; . GO GO:0005654; C:nucleoplasm; IDA:HPA; . GO GO:0005634; C:nucleus; IDA:HPA; . GO GO:0008124; F:4-alpha-hydroxytetrahydrobiopterin dehydratase activity; EXP:Reactome; . GO GO:0042802; F:identical protein binding; IPI:IntAct; . GO GO:0004505; F:phenylalanine 4-monooxygenase activity; IEA:Ensembl; . GO GO:0003713; F:transcription coactivator activity; TAS:ProtInc; . GO GO:0006559; P:L-phenylalanine catabolic process; TAS:Reactome; . GO GO:0045893; P:positive regulation of transcription; DNA-templated; IEA:Ensembl GO GO:0051291; P:protein heterooligomerization; IEA:Ensembl; . GO GO:0051289; P:protein homotetramerization; IEA:Ensembl; . GO GO:0043496; P:regulation of protein homodimerization activity; IEA:Ensembl; . GO GO:0006729; P:tetrahydrobiopterin biosynthetic process; IEA:UniProtKB-KW; . GO GO:0006351; P:transcription; DNA-templated; IEA:UniProtKB-KW Gene3D 3.30.1360.20; -; 1; . HAMAP MF_00434; Pterin_4_alpha; 1; . InterPro IPR001533; Trans/pterin_deHydtase; . Pfam PF01329; Pterin_4a; 1; . SUPFAM SSF55248; SSF55248; 1; .

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• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
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• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
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